ANDROGEN DEFICIENCY IN MALE

Symptoms and signs suggestive of
androgen deficiency in men

• Incomplete sexual development, eunuchoidism,
aspermia
• Reduced sexual desire (libido) and activity
• Decreased spontaneous erections
• Breast discomfort, gynecomastia
• Loss of body (axillary and pubic) hair, reduced shaving
• Very small or shrinking testes (especially < 5 mL)
• Inability to father children, low or zero sperm counts
• Height loss, low-trauma fracture, low bone mineral
density
• Reduced muscle bulk and strength
• Hot flushes, sweats

AUTOSOMAL DOMINENT CONDITIONS

Autosomal dominant inheritance is seen in:


Achondroplasia, Acute intermittent porphyria, Adult polycystic kidney disease, Ehlers-Danlos syndrome, Familial adenomatous polyposis, Gilbert's syndrome, Hereditary sensory and motor neuropathy, Hereditary spherocytosis, Huntington's disease, Hyperlipidaemia type II, Malignant hyperthermia, Marfan's syndrome, Myotonia congenita, Myotonic dystrophy, Neurofibromatosis, Osteogenesis imperfecta type 1, Noonan's syndrome, Polyposis coli, Rotor syndrome, Retinoblastoma, Tuberose sclerosis, Von Hippel-Lindau disease, von Willebrand's disease

ISOTRETINOIN IN ACNE

Features of oral isotretinoin treatment
• For patients with severe acne
• For patients unresponsive to conventional therapy
• For acne patients experiencing psychological distress
• Extremely effective, as it targets all causes of acne
• Duration of treatment and daily dose are individualised
• Low starting dose is used that may be gradually increased, as
tolerated
• Side effects are usually manageable
• Warn of mood changes and the potential risk of depression
• Warn about contraception and teratogenicity

ISOTRETINOIN IN ACNE

Features of oral isotretinoin treatment
• For patients with severe acne
• For patients unresponsive to conventional therapy
• For acne patients experiencing psychological distress
• Extremely effective, as it targets all causes of acne
• Duration of treatment and daily dose are individualised
• Low starting dose is used that may be gradually increased, as
tolerated
• Side effects are usually manageable
• Warn of mood changes and the potential risk of depression
• Warn about contraception and teratogenicity

ACNE TREATMENT

Tips for antibiotic
therapy

• Do not use topical and
oral antibiotics at the
same time
• Use oral antibiotics for a
6-12-week course
• If a longer course of oral
antibiotics is required, use
benzoyl peroxide for a
week between courses
• Warn of side effects of
antibiotic therapy,
particularly
photosensitivity with
doxycycline