AUTOSOMAL DOMINENT CONDITIONS

Autosomal dominant inheritance is seen in:


Achondroplasia, Acute intermittent porphyria, Adult polycystic kidney disease, Ehlers-Danlos syndrome, Familial adenomatous polyposis, Gilbert's syndrome, Hereditary sensory and motor neuropathy, Hereditary spherocytosis, Huntington's disease, Hyperlipidaemia type II, Malignant hyperthermia, Marfan's syndrome, Myotonia congenita, Myotonic dystrophy, Neurofibromatosis, Osteogenesis imperfecta type 1, Noonan's syndrome, Polyposis coli, Rotor syndrome, Retinoblastoma, Tuberose sclerosis, Von Hippel-Lindau disease, von Willebrand's disease

ISOTRETINOIN IN ACNE

Features of oral isotretinoin treatment
• For patients with severe acne
• For patients unresponsive to conventional therapy
• For acne patients experiencing psychological distress
• Extremely effective, as it targets all causes of acne
• Duration of treatment and daily dose are individualised
• Low starting dose is used that may be gradually increased, as
tolerated
• Side effects are usually manageable
• Warn of mood changes and the potential risk of depression
• Warn about contraception and teratogenicity

ISOTRETINOIN IN ACNE

Features of oral isotretinoin treatment
• For patients with severe acne
• For patients unresponsive to conventional therapy
• For acne patients experiencing psychological distress
• Extremely effective, as it targets all causes of acne
• Duration of treatment and daily dose are individualised
• Low starting dose is used that may be gradually increased, as
tolerated
• Side effects are usually manageable
• Warn of mood changes and the potential risk of depression
• Warn about contraception and teratogenicity

ACNE TREATMENT

Tips for antibiotic
therapy

• Do not use topical and
oral antibiotics at the
same time
• Use oral antibiotics for a
6-12-week course
• If a longer course of oral
antibiotics is required, use
benzoyl peroxide for a
week between courses
• Warn of side effects of
antibiotic therapy,
particularly
photosensitivity with
doxycycline

ACNE MANAGEMENT

IMPORTANT POINTS HISTORY AND EXAMINATION


History

• How long have you had
pimples for?
• Are there any triggers?
• Is there a family history?
• What treatments have you
had? How long did you
follow each treatment?
• What was the most
effective treatment? Why
did you stop it?
• How do you feel about
your skin? Does it stop
you from doing anything?

Examination

• Assess the severity and
whether there is any
scarring.
• Determine any
psychological impact.